AustralieFrV1, Main, Exploration, bibRecord, 000749

Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.

Identifieur interne : 000749 ( Main/Exploration ); précédent : 000748; suivant : 000750

Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.

Auteurs : Miguel Martin [Espagne] ; Frankie A. Holmes [États-Unis] ; Bent Ejlertsen [Danemark] ; Suzette Delaloge [France] ; Beverly Moy [États-Unis] ; Hiroji Iwata [Japon] ; Gunter Von Minckwitz [Allemagne] ; Stephen K L. Chia [Canada] ; Janine Mansi [Royaume-Uni] ; Carlos H. Barrios [Brésil] ; Michael Gnant [Autriche] ; Zorica Tomaševi [Serbie] ; Neelima Denduluri [États-Unis] ; Robert Šeparovi [Croatie] ; Erhan Gokmen [Turquie] ; Anna Bashford [Nouvelle-Zélande] ; Manuel Ruiz Borrego [Espagne] ; Sung-Bae Kim [Corée du Sud] ; Erik Hugger Jakobsen [Danemark] ; Audrone Ciceniene [Lituanie] ; Kenichi Inoue [Japon] ; Friedrich Overkamp [Allemagne] ; Joan B. Heijns [Pays-Bas] ; Anne C. Armstrong [Royaume-Uni] ; John S. Link [États-Unis] ; Anil Abraham Joy [Canada] ; Richard Bryce [États-Unis] ; Alvin Wong [États-Unis] ; Susan Moran [États-Unis] ; Bin Yao [États-Unis] ; Feng Xu [États-Unis] ; Alan Auerbach [États-Unis] ; Marc Buyse [Belgique] ; Arlene Chan [Australie]

Source :

The Lancet. Oncology [ 1474-5488 ] ; 2017.

RBID : pubmed:29146401

Abstract

ExteNET showed that 1 year of neratinib, an irreversible pan-HER tyrosine kinase inhibitor, significantly improves 2-year invasive disease-free survival after trastuzumab-based adjuvant therapy in women with HER2-positive breast cancer. We report updated efficacy outcomes from a protocol-defined 5-year follow-up sensitivity analysis and long-term toxicity findings.

DOI: 10.1016/S1470-2045(17)30717-9
PubMed: 29146401

Affiliations:

Le document en format XML

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<author><name sortKey="Martin, Miguel" sort="Martin, Miguel" uniqKey="Martin M" first="Miguel" last="Martin">Miguel Martin</name>
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<author><name sortKey="Iwata, Hiroji" sort="Iwata, Hiroji" uniqKey="Iwata H" first="Hiroji" last="Iwata">Hiroji Iwata</name>
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<author><name sortKey="Chia, Stephen K L" sort="Chia, Stephen K L" uniqKey="Chia S" first="Stephen K L" last="Chia">Stephen K L. Chia</name>
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<author><name sortKey="Mansi, Janine" sort="Mansi, Janine" uniqKey="Mansi J" first="Janine" last="Mansi">Janine Mansi</name>
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<author><name sortKey="Barrios, Carlos H" sort="Barrios, Carlos H" uniqKey="Barrios C" first="Carlos H" last="Barrios">Carlos H. Barrios</name>
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<author><name sortKey="Gnant, Michael" sort="Gnant, Michael" uniqKey="Gnant M" first="Michael" last="Gnant">Michael Gnant</name>
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<author><name sortKey="Denduluri, Neelima" sort="Denduluri, Neelima" uniqKey="Denduluri N" first="Neelima" last="Denduluri">Neelima Denduluri</name>
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<author><name sortKey="Separovi, Robert" sort="Separovi, Robert" uniqKey="Separovi R" first="Robert" last="Šeparovi">Robert Šeparovi</name>
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<author><name sortKey="Gokmen, Erhan" sort="Gokmen, Erhan" uniqKey="Gokmen E" first="Erhan" last="Gokmen">Erhan Gokmen</name>
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<wicri:regionArea>Ege University Faculty of Medicine, Izmir</wicri:regionArea>
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<author><name sortKey="Bashford, Anna" sort="Bashford, Anna" uniqKey="Bashford A" first="Anna" last="Bashford">Anna Bashford</name>
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<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Auckland Hospital, Auckland</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Ruiz Borrego, Manuel" sort="Ruiz Borrego, Manuel" uniqKey="Ruiz Borrego M" first="Manuel" last="Ruiz Borrego">Manuel Ruiz Borrego</name>
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</author>
<author><name sortKey="Kim, Sung Bae" sort="Kim, Sung Bae" uniqKey="Kim S" first="Sung-Bae" last="Kim">Sung-Bae Kim</name>
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<country xml:lang="fr">Corée du Sud</country>
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</affiliation>
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<author><name sortKey="Jakobsen, Erik Hugger" sort="Jakobsen, Erik Hugger" uniqKey="Jakobsen E" first="Erik Hugger" last="Jakobsen">Erik Hugger Jakobsen</name>
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<author><name sortKey="Ciceniene, Audrone" sort="Ciceniene, Audrone" uniqKey="Ciceniene A" first="Audrone" last="Ciceniene">Audrone Ciceniene</name>
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</author>
<author><name sortKey="Inoue, Kenichi" sort="Inoue, Kenichi" uniqKey="Inoue K" first="Kenichi" last="Inoue">Kenichi Inoue</name>
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</author>
<author><name sortKey="Overkamp, Friedrich" sort="Overkamp, Friedrich" uniqKey="Overkamp F" first="Friedrich" last="Overkamp">Friedrich Overkamp</name>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Heijns, Joan B" sort="Heijns, Joan B" uniqKey="Heijns J" first="Joan B" last="Heijns">Joan B. Heijns</name>
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</author>
<author><name sortKey="Armstrong, Anne C" sort="Armstrong, Anne C" uniqKey="Armstrong A" first="Anne C" last="Armstrong">Anne C. Armstrong</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, Christie Hospital Manchester, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
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<region type="région" nuts="1">Grand Manchester</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Link, John S" sort="Link, John S" uniqKey="Link J" first="John S" last="Link">John S. Link</name>
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<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Joy, Anil Abraham" sort="Joy, Anil Abraham" uniqKey="Joy A" first="Anil Abraham" last="Joy">Anil Abraham Joy</name>
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<country xml:lang="fr">Canada</country>
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</author>
<author><name sortKey="Bryce, Richard" sort="Bryce, Richard" uniqKey="Bryce R" first="Richard" last="Bryce">Richard Bryce</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Puma Biotechnology Inc, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wong, Alvin" sort="Wong, Alvin" uniqKey="Wong A" first="Alvin" last="Wong">Alvin Wong</name>
<affiliation wicri:level="2"><nlm:affiliation>Puma Biotechnology Inc, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Puma Biotechnology Inc, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moran, Susan" sort="Moran, Susan" uniqKey="Moran S" first="Susan" last="Moran">Susan Moran</name>
<affiliation wicri:level="2"><nlm:affiliation>Puma Biotechnology Inc, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Puma Biotechnology Inc, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yao, Bin" sort="Yao, Bin" uniqKey="Yao B" first="Bin" last="Yao">Bin Yao</name>
<affiliation wicri:level="2"><nlm:affiliation>Puma Biotechnology Inc, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Puma Biotechnology Inc, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Feng" sort="Xu, Feng" uniqKey="Xu F" first="Feng" last="Xu">Feng Xu</name>
<affiliation wicri:level="2"><nlm:affiliation>Puma Biotechnology Inc, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Puma Biotechnology Inc, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Auerbach, Alan" sort="Auerbach, Alan" uniqKey="Auerbach A" first="Alan" last="Auerbach">Alan Auerbach</name>
<affiliation wicri:level="2"><nlm:affiliation>Puma Biotechnology Inc, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Puma Biotechnology Inc, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buyse, Marc" sort="Buyse, Marc" uniqKey="Buyse M" first="Marc" last="Buyse">Marc Buyse</name>
<affiliation wicri:level="1"><nlm:affiliation>International Drug Development Institute, Louvain-la-Neuve, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>International Drug Development Institute, Louvain-la-Neuve</wicri:regionArea>
<wicri:noRegion>Louvain-la-Neuve</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chan, Arlene" sort="Chan, Arlene" uniqKey="Chan A" first="Arlene" last="Chan">Arlene Chan</name>
<affiliation wicri:level="1"><nlm:affiliation>Breast Cancer Research Centre-Western Australia, Perth, WA, Australia; Curtin University, Perth, WA, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Breast Cancer Research Centre-Western Australia, Perth, WA, Australia; Curtin University, Perth, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.</title>
<author><name sortKey="Martin, Miguel" sort="Martin, Miguel" uniqKey="Martin M" first="Miguel" last="Martin">Miguel Martin</name>
<affiliation wicri:level="3"><nlm:affiliation>Instituto de Investigación Sanitaria Gregorio Marañón, Grupo Español de Investigación en Cáncer de Mama (GEICAM), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Universidad Complutense, Madrid, Spain. Electronic address: mmartin@geicam.org.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Instituto de Investigación Sanitaria Gregorio Marañón, Grupo Español de Investigación en Cáncer de Mama (GEICAM), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Universidad Complutense, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
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</affiliation>
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<author><name sortKey="Holmes, Frankie A" sort="Holmes, Frankie A" uniqKey="Holmes F" first="Frankie A" last="Holmes">Frankie A. Holmes</name>
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<country xml:lang="fr">États-Unis</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name>
<affiliation wicri:level="3"><nlm:affiliation>Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Rigshospitalet, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Delaloge, Suzette" sort="Delaloge, Suzette" uniqKey="Delaloge S" first="Suzette" last="Delaloge">Suzette Delaloge</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut Gustave Roussy, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Gustave Roussy, Villejuif</wicri:regionArea>
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<country xml:lang="fr">Japon</country>
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<country xml:lang="fr">Allemagne</country>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>BC Cancer Agency, Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Barrios, Carlos H" sort="Barrios, Carlos H" uniqKey="Barrios C" first="Carlos H" last="Barrios">Carlos H. Barrios</name>
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<country xml:lang="fr">Brésil</country>
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</affiliation>
</author>
<author><name sortKey="Gnant, Michael" sort="Gnant, Michael" uniqKey="Gnant M" first="Michael" last="Gnant">Michael Gnant</name>
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<country xml:lang="fr">Autriche</country>
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<author><name sortKey="Tomasevi, Zorica" sort="Tomasevi, Zorica" uniqKey="Tomasevi Z" first="Zorica" last="Tomaševi">Zorica Tomaševi</name>
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</author>
<author><name sortKey="Denduluri, Neelima" sort="Denduluri, Neelima" uniqKey="Denduluri N" first="Neelima" last="Denduluri">Neelima Denduluri</name>
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<wicri:regionArea>Virginia Cancer Specialists, Arlington, VA</wicri:regionArea>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Separovi, Robert" sort="Separovi, Robert" uniqKey="Separovi R" first="Robert" last="Šeparovi">Robert Šeparovi</name>
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<country xml:lang="fr">Croatie</country>
<wicri:regionArea>University Hospital for Tumors, University Hospital Center "Sestre milosrdnice", Zagreb</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Gokmen, Erhan" sort="Gokmen, Erhan" uniqKey="Gokmen E" first="Erhan" last="Gokmen">Erhan Gokmen</name>
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<author><name sortKey="Bashford, Anna" sort="Bashford, Anna" uniqKey="Bashford A" first="Anna" last="Bashford">Anna Bashford</name>
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<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Auckland Hospital, Auckland</wicri:regionArea>
<wicri:noRegion>Auckland</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruiz Borrego, Manuel" sort="Ruiz Borrego, Manuel" uniqKey="Ruiz Borrego M" first="Manuel" last="Ruiz Borrego">Manuel Ruiz Borrego</name>
<affiliation wicri:level="1"><nlm:affiliation>Oncology Department, Hospital Universitario Virgen del Rocio, Seville, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Oncology Department, Hospital Universitario Virgen del Rocio, Seville</wicri:regionArea>
<wicri:noRegion>Seville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Sung Bae" sort="Kim, Sung Bae" uniqKey="Kim S" first="Sung-Bae" last="Kim">Sung-Bae Kim</name>
<affiliation wicri:level="3"><nlm:affiliation>Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jakobsen, Erik Hugger" sort="Jakobsen, Erik Hugger" uniqKey="Jakobsen E" first="Erik Hugger" last="Jakobsen">Erik Hugger Jakobsen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, Lillebaelt Hospital, Vejle, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Oncology, Lillebaelt Hospital, Vejle</wicri:regionArea>
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</author>
<author><name sortKey="Ciceniene, Audrone" sort="Ciceniene, Audrone" uniqKey="Ciceniene A" first="Audrone" last="Ciceniene">Audrone Ciceniene</name>
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<wicri:regionArea>Oncology Institute of Vilnius University, Vilnius</wicri:regionArea>
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</author>
<author><name sortKey="Inoue, Kenichi" sort="Inoue, Kenichi" uniqKey="Inoue K" first="Kenichi" last="Inoue">Kenichi Inoue</name>
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<wicri:regionArea>Breast Oncology, Saitama Cancer Center, Kita-Adachi</wicri:regionArea>
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</placeName>
</affiliation>
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<author><name sortKey="Heijns, Joan B" sort="Heijns, Joan B" uniqKey="Heijns J" first="Joan B" last="Heijns">Joan B. Heijns</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Amphia Hospital, Breda, Netherlands.</nlm:affiliation>
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<wicri:regionArea>Department of Medical Oncology, Amphia Hospital, Breda</wicri:regionArea>
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</author>
<author><name sortKey="Armstrong, Anne C" sort="Armstrong, Anne C" uniqKey="Armstrong A" first="Anne C" last="Armstrong">Anne C. Armstrong</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Oncology, Christie Hospital Manchester, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
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<region type="région" nuts="1">Grand Manchester</region>
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<affiliation wicri:level="2"><nlm:affiliation>Breastlink Medical Group Inc, Santa Ana, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Breastlink Medical Group Inc, Santa Ana, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Joy, Anil Abraham" sort="Joy, Anil Abraham" uniqKey="Joy A" first="Anil Abraham" last="Joy">Anil Abraham Joy</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Alberta, Department of Oncology, Cross Cancer Institute, Edmonton, AB, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of Alberta, Department of Oncology, Cross Cancer Institute, Edmonton, AB</wicri:regionArea>
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</author>
<author><name sortKey="Bryce, Richard" sort="Bryce, Richard" uniqKey="Bryce R" first="Richard" last="Bryce">Richard Bryce</name>
<affiliation wicri:level="2"><nlm:affiliation>Puma Biotechnology Inc, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Puma Biotechnology Inc, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
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<author><name sortKey="Wong, Alvin" sort="Wong, Alvin" uniqKey="Wong A" first="Alvin" last="Wong">Alvin Wong</name>
<affiliation wicri:level="2"><nlm:affiliation>Puma Biotechnology Inc, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Puma Biotechnology Inc, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moran, Susan" sort="Moran, Susan" uniqKey="Moran S" first="Susan" last="Moran">Susan Moran</name>
<affiliation wicri:level="2"><nlm:affiliation>Puma Biotechnology Inc, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Puma Biotechnology Inc, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yao, Bin" sort="Yao, Bin" uniqKey="Yao B" first="Bin" last="Yao">Bin Yao</name>
<affiliation wicri:level="2"><nlm:affiliation>Puma Biotechnology Inc, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Puma Biotechnology Inc, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Feng" sort="Xu, Feng" uniqKey="Xu F" first="Feng" last="Xu">Feng Xu</name>
<affiliation wicri:level="2"><nlm:affiliation>Puma Biotechnology Inc, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Puma Biotechnology Inc, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Auerbach, Alan" sort="Auerbach, Alan" uniqKey="Auerbach A" first="Alan" last="Auerbach">Alan Auerbach</name>
<affiliation wicri:level="2"><nlm:affiliation>Puma Biotechnology Inc, Los Angeles, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Puma Biotechnology Inc, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buyse, Marc" sort="Buyse, Marc" uniqKey="Buyse M" first="Marc" last="Buyse">Marc Buyse</name>
<affiliation wicri:level="1"><nlm:affiliation>International Drug Development Institute, Louvain-la-Neuve, Belgium.</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>International Drug Development Institute, Louvain-la-Neuve</wicri:regionArea>
<wicri:noRegion>Louvain-la-Neuve</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chan, Arlene" sort="Chan, Arlene" uniqKey="Chan A" first="Arlene" last="Chan">Arlene Chan</name>
<affiliation wicri:level="1"><nlm:affiliation>Breast Cancer Research Centre-Western Australia, Perth, WA, Australia; Curtin University, Perth, WA, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Breast Cancer Research Centre-Western Australia, Perth, WA, Australia; Curtin University, Perth, WA</wicri:regionArea>
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</affiliation>
</author>
</analytic>
<series><title level="j">The Lancet. Oncology</title>
<idno type="eISSN">1474-5488</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">ExteNET showed that 1 year of neratinib, an irreversible pan-HER tyrosine kinase inhibitor, significantly improves 2-year invasive disease-free survival after trastuzumab-based adjuvant therapy in women with HER2-positive breast cancer. We report updated efficacy outcomes from a protocol-defined 5-year follow-up sensitivity analysis and long-term toxicity findings.</div>
</front>
</TEI>
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<country name="Australie"><noRegion><name sortKey="Chan, Arlene" sort="Chan, Arlene" uniqKey="Chan A" first="Arlene" last="Chan">Arlene Chan</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000749 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000749 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:29146401
   |texte=   Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:29146401" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.

Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.

Source :

Abstract

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Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
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